Leukemia M5b belongs to one of the types of acute myeloid leukemia, and the prognosis is generally poor if the TLS/ERG fusion gene is positive. 1. TLS and ERG are both protein coding genes. TLS is involved in cellular processes such as regulation of gene expression, maintenance of gene integrity, mRNA-RNA processing, etc. ERG is involved in cell proliferation, angiogenesis, differentiation and apoptosis, and plays an important role in this process. A rare non-random translocation of the TLS and ERG genes produces a TLS/ERG fusion gene. leukemia patients with a positive TLS/ERG fusion gene have a poorer prognosis and are independent risk factors for leukemia patient risk assessment and prognosis analysis. 2. By itself, acute leukemia M5b is a serious hematologic malignant disease, which requires timely chemotherapy with drugs such as cytarabine and Zoerythromycin to alleviate the condition and prolong the survival period. Specific diagnosis and treatment should be carried out under the guidance of physicians.