Skin atrophy caused by Trimethoprim injection requires prompt hospitalization and is usually difficult to recover. As a long-acting glucocorticoid, Tretinoin Injection has strong and long-lasting anti-inflammatory and anti-allergic effects, and is used by intramuscular injection for the treatment of diffuse rheumatoid arthritis, dermatologic diseases, allergic diseases and other diseases. Skin whitening, skin atrophy and other manifestations may occur at the injection site, which are more difficult to cure at present. Tretinoin Injection should be used under the guidance of a medical professional, and possible adverse reactions include obesity, hypertension, and hypokalemia. Tretinoin Injection should not be used in active gastric ulcers, diabetes, or any uncontrolled infectious disease.