Scrotal dampness, coolness may be long-term sedentary, sweating and other physiological factors, without the need for medication, if the chronic prostatitis, scrotal eczema and other conditions caused by the need to comply with the doctor’s orders to use levofloxacin, dexamethasone and other medications. 1. Physiological factors: usually patients sitting for a long time or in a hot environment, resulting in more sweating, there may be a scrotum moist, cool situation, is a normal physiological phenomenon, usually do not need to use the drug treatment. 2. Chronic prostatitis: usually patients can follow the doctor’s instructions to use levofloxacin, doxycycline and other antibacterial drugs treatment, but also with the use of ibuprofen, indomethacin and other non-steroidal anti-inflammatory drugs, to alleviate the symptoms. And some patients can also use doxazosin, tamsulosin and other alpha-blockers to relax the bladder neck and posterior urethral muscles, so as to improve urinary function. 3. Scrotal eczema: usually patients can be treated with topical mometasone furoate, dexamethasone, hydrocortisone and other glucocorticosteroids, and some patients can also be treated with topical tacrolimus ointment, pimecrolimus cream and other immunomodulators. Some patients can also be combined with the application of antihistamines such as diphenhydramine and chlorpheniramine. It is recommended that patients with scrotal dampness and coldness should follow the doctor’s instructions to use reasonable medication, and if necessary, cooperate with the doctor for other treatments.