Itchy, cracked and peeling hands may be related to fungal infections, eczema and palmoplantar pustulosis, and medications can be chosen from antifungal medications, antiallergic medications and retinoids. 1. Fungal infections: after a fungal examination to determine the cause of fungal infections, you can choose to have the effect of antifungal drugs, such as terbinafine tablets, and then topical sertaconazole nitrate cream. 2. Hand eczema: hand eczema caused by itching, cracking and peeling, you can choose loratadine tablets and ibastine tablets under the guidance of the doctor, and at the same time, combined with the topical use of dieldrin cream, mometasone furoate cream and other glucocorticosteroid ointment. 3. Palmoplantar pustulosis: this is a special kind of psoriasis, you can use glucocorticoid cream such as halometasone cream, can be combined with oral retinoids such as avitamin A capsules. Itchy, cracked and peeling hands are caused by many reasons, in the treatment, please actively go to the regular hospital to accept the examination, after the diagnosis can be taken targeted treatment. The medication should be used in accordance with the doctor’s instructions.