The purpose of vaccination is to avoid or reduce the chance of contracting these infectious diseases by immunizing the human organism with a certain vaccine, vaccine or toxoid, etc., and by making the organism immune to these infectious diseases through an immune response. Vaccination itself does not cause further development of heart malformations, but some reactions of varying severity may occur after certain vaccinations. Generally speaking, local reactions have no effect on heart function, while some systemic reactions (such as fever) may increase the burden on the heart. Therefore, general vaccination is not recommended for children with congenital heart disease who usually have poor heart function, especially for children who have frequent heart failure or are in chronic heart failure. However, children who usually have good heart function and good activity endurance can be vaccinated. For children who are preparing for surgical treatment, it is best to avoid vaccination for 1 month before surgery to prevent adverse reactions caused by the low immunity of the body due to surgical blows. Children after extracorporeal circulation surgery can resume vaccination after their heart function returns to normal in 3 months after surgery and 1 month after interventional surgery, and children who were not vaccinated as planned before surgery due to heart function and other problems should complete the missing parts according to the vaccination procedure. For children undergoing palliative surgery, if the heart function is still poor after surgery or the heart deformity is still obvious, the decision of whether to perform preventive vaccination should be made on a case-by-case basis. Therefore, the issue of vaccination for children with congenital heart disease must be analyzed on a case-by-case basis, and the view that no vaccination should be given is not correct. The specific indications can be controlled by the staff of vaccination.