Nighttime toothache can not sleep may be due to pulpitis, wisdom teeth pericoronitis, apical periodontitis and other diseases, the patient needs to actively treat the primary disease, for the cause of the disease to take medication, surgical treatment and other methods, so as to improve the symptoms of pain. 1. Pulpitis: toothache at night can not sleep may be due to pulpitis. Patients can choose to take surgical treatment, such as direct pulp capping, indirect pulp capping, root canal treatment, etc. Most patients can improve the symptoms of pain after treatment. 2. Wisdom tooth pericoronitis: toothache at night can not sleep may be due to wisdom tooth pericoronitis. Patients follow the doctor’s instructions to take local rinsing, commonly used hydrogen peroxide solution, saline, potassium permanganate solution, chlorhexidine and so on. Or oral antibiotic drugs, such as metronidazole, clindamycin and so on. If necessary, incision and drainage can be taken, peri-coronal gingival flap resection. 3. apical periodontitis: night toothache can not sleep is also considered to be due to apical periodontitis, the patient can follow the doctor’s instructions oral antibiotic drugs, such as metronidazole, cefuroxime, etc., the main should be taken to the root canal treatment, dental pulp hemotransfusion reconstruction surgery. There are many reasons why you can’t sleep at night with toothache, so we recommend that you find out the cause of the problem. Once diagnosed, treatment measures need to be taken actively. Drugs should be used under the guidance of a physician.