Glycine insulin at bedtime may be hypoglycemic. Glycine insulin is a long-acting insulin analog that has a long duration of action, up to 30 hours, with no significant peak of action. Injections at bedtime provide better control of fasting blood glucose, and injections are not related to whether or not you eat. It can also be injected in the morning if bedtime is not convenient, or subcutaneously at a fixed time of day for maintaining basal blood glucose stability throughout the day. Glycinated insulin is given once daily and can be given at any time throughout the day, preferably at the same time each day. Clinically, it is often recommended that the injection be given at 9 ~ 10 pm for better control of fasting blood glucose the next morning. However, glycemic insulin injection should also pay attention to the occurrence of nighttime hypoglycemia. If hypoglycemia occurs, the dose should be reduced, and if postprandial blood glucose is high, it should be treated with short-acting insulin. Glycine insulin should be used under the guidance of a doctor and the indications should be strictly controlled. If there is any allergy or discomfort, consult your doctor in time and use it reasonably under your doctor’s guidance.