Myeloma is a malignant neoplasm involving bone marrow hematopoietic cells that is prone to occur in middle age and later life. The main lesion of myeloma exists in the bone structure, so the main symptom is continuous and increasing bone pain, which will also be accompanied by anemia, recurrent infections and neurological damage, etc. The common symptoms of myeloma include the following: 1. Bone pain: Bone pain caused by myeloma will usually be very obvious late at night, and the pain will affect sleep if it is severe, and the pain often continues to be located around the spine and pelvis. If patients have multiple bone metastases and myeloma, the pain will be very severe and most of them will produce pathological fractures; 2. Most of them are bacterial infections, but also fungal and viral infections. Patients are prone to bacterial pneumonia, urinary tract infection, sepsis and other diseases; 4. hypercalcemia: often manifested as headache, vomiting, polyuria, constipation, etc., which can lead to cardiac arrhythmia, coma or even death in severe cases; 5. neurological damage: patients with myeloma or concurrent pathological fractures can stimulate or compress spinal nerves, resulting in radiological pain, limb dysfunction, or even paraplegia; 6. kidney damage: half of the patients More than half of the patients who have routine urine examination may have red blood cells, white blood cells and tubular type, suggesting kidney damage. Patients with myeloma should follow medical advice to choose radiotherapy or chemotherapy, and patients with fractures may need to undergo surgery.