Due to the severity of the disease and the individual physique there are differences, taking tofacitibine citrate tablets after the effect of time is not the same, in general, most patients in 7-15 days may see the effect. Tofacitabine Citrate Tablets is a prescription medication for the treatment of moderately to severely active rheumatoid arthritis. This medication is indicated for adult patients in whom methotrexate is insufficiently effective or intolerable, and such patients may be treated with methotrexate alone or in combination with methotrexate or other non-bio-improving anti-rheumatic drugs. The time to effect is not the same for different patients, with most patients seeing results in 7-15 days. Tofacitibe citrate tablets are not recommended for use in combination with biological anti-rheumatic drugs or potent immunosuppressants such as cyclosporine and azathioprine. This drug is associated with the potential for adverse reactions such as serious infections, gastrointestinal perforation, abnormal laboratory tests, malignant tumors and lymphoproliferative disorders, anemia, insomnia, and dyspnea. There are no contraindications to use. Attention should be paid to monitoring for signs or symptoms of infection, regular blood tests, blood glucose, blood lipids and liver function during administration. It is recommended to follow the doctor’s instructions to use tofacitibine citrate tablets and avoid self-medication.