There are many kinds of arrhythmias, some of which do not require treatment and can be recovered by it adjusting lifestyle habits and other measures, but some malignant arrhythmias affect our lives and must be treated formally in a hospital. What treatment measures will be taken clinically for these malignant arrhythmias? 1. Class I antiarrhythmic drugs: they cannot improve the patient’s prognosis, but increase the risk of death. 2. Class II antiarrhythmic drugs: β-blockers are the most effective drugs for reducing sudden death and reducing overall mortality in patients with post-infarction and chronic heart failure, and are therefore the drugs of choice for the prevention and treatment of malignant ventricular arrhythmias. 3.Class III antiarrhythmic drugs: amiodarone and sotalol, which can be used for the prevention and treatment of malignant ventricular arrhythmias in patients who are not conditionally treated with ICD; generally, amiodarone is the main choice, followed by sotalol; amiodarone is the first choice for elderly patients with poor cardiac function, and sotalol is available for young patients with good cardiac function. 4, Class IV arrhythmia drugs: Verapamil can be used for idiopathic left ventricular ventricular tachycardia, ventricular tachycardia originating from the right ventricular outflow tract and polymorphic ventricular tachycardia with normal QT interval and short paired intervals starting with premature ventricular beats. 5, tip-twisting ventricular tachycardia or ventricular fibrillation occurring in patients with congenital QT interval prolongation syndrome, treatment is preferred to β-blockers or in combination with pacemakers. 6.Surgical treatment: It is suitable for patients who have clear foci of ventricular tachycardia, who receive regular drug treatment but still have frequent recurrence of symptoms, and who can be induced by clinical electrophysiological examination of persistent ventricular tachycardia. The surgical approach must preserve cardiac function. Surgical methods include: excision of ventricular tachycardia foci or ventricular wall tumors, total or partial endocardial circumcision of ventricular tachycardia foci, endocardial cryotherapy or laser treatment. 7. Ablation therapy: for persistent ventricular tachycardia that has failed to respond to drug therapy, recurrent ventricular tachycardia, or placement of an anti-tachycardia pacing device. Successful ablation therapy is determined by precise endocardial labeling, localization and destruction at the site of myocardial triggering of ventricular tachycardia. 8. Ventricular fibrillation in Brugada syndrome has no reliable pharmacological treatment, amiodarone can be tried and should be treated with ICD. 9, ICD therapy should be preferred for the treatment of malignant ventricular arrhythmias; the total evaluation of the efficacy of antiarrhythmic drugs is not reliable enough.