The Department of Hematology of Jiangmen Wuyi Hospital of Traditional Chinese Medicine has been adhering to the tenet of patient-centered and all-for-patients, and has been diligently researching and improving our medical care technology. Since the acquisition of COM.TEC blood cell separator in 2012, our department has carried out projects of stem cell collection, white blood cell collection, white blood cell removal, red blood cell removal, and in February 2015, we started to carry out a new technology – plasma replacement using this instrument. Through the development of this technology, we bring more and better treatments and options to patients, and also take our medical care technology to the next level. Plasma exchange (PE) is one of the most important means of purifying blood in the modern biomedical engineering neighborhood. Plasma exchange therapy is used in a wide range of clinical applications, involving a variety of diseases in the kidney, neurology, hematology, and several other systems, and is especially prominent in the treatment of refractory and critical illnesses. Plasma exchange reduces harmful substances in the blood to remove large molecular weight proteins from the patient’s body. The patient’s blood is drawn out of the body, separated from the whole blood by membrane plasma separation and discarded, and then supplemented with an equal amount of fresh frozen plasma or human albumin and other replacement solutions, which can remove various metabolic toxins and disease-causing factors from the patient’s body, thus achieving therapeutic purposes. Since plasma exchange can remove not only small and medium molecules of metabolic toxins, but also large molecules such as proteins and immune complexes, the removal rate of harmful substances is much better than that of hemodialysis, hemofiltration and hemoperfusion. Indications for plasma exchange: 1. poisoning from various causes: muscarinic poisoning, poisonous mushroom poisoning, organophosphorus pesticide poisoning, acute drug poisoning, poisonous rodent poisoning, acute heavy metal poisoning (such as arsenical hydrogen poisoning), poisonous snake bite poisoning and food poisoning, etc. 2. renal diseases: pulmonary hemorrhagic nephritis syndrome, lupus nephritis, purpura nephritis, IgA nephropathy, membranoproliferative nephritis and acute rejection of transplanted kidney. 3. 3, autoimmune diseases (commonly known as rheumatic diseases): systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, rheumatoid arthritis, etc. 4, hematologic diseases: autoimmune hemolytic anemia, hemolytic uremic syndrome, etc., the use of plasma exchange can rapidly remove the anti-red blood cell antibodies in the patient’s body to reduce the occurrence of hemolysis; for thrombotic thrombocytopenic purpura 5.Nervous system diseases: such as myasthenia gravis, polyneuritis, neurological damage of systemic lupus erythematosus and multiple sclerosis, plasma replacement can quickly remove harmful substances in plasma, so that the damage of neural tissue can be reduced to the minimum, thus enabling patients to quickly get out of danger. 6.Acute and chronic liver failure: such as fulminant viral hepatitis, drug-induced liver damage, liver coma, etc. Plasma replacement can rapidly remove the metabolic waste accumulated in the body due to abnormal liver function and relieve the condition. 7.Familial hypercholesterolemia: plasma replacement can eliminate excessive cholesterol in the patient’s body and inhibit the development of atherosclerosis. 8.Thyroid crisis: plasma replacement can Remove excessive hormones from the body and supply plasma proteins that freely bind to thyroid hormones, stabilizing the condition.