Shock is a series of pathophysiological changes that occur when pathogenic factors act on the body to produce a reduction in effective circulating blood volume, resulting in microcirculatory disorders in peripheral tissues and organs that cannot meet the metabolic demands of the tissues. The causes of shock are: 1, infectious shock 2, hypovolemic shock 3, cardiogenic shock 4, neurogenic shock 5, anaphylactic shock. Shock and enterogenic infection, shock 30 minutes can have intestinal flora shift, shock 90 minutes enterogenic infection will occur. 48 hours after the intestinal flora is severely dysbiosis. MOF are present sepsis, timely application of three generations of cephalosporin may be timely control of infection. Diagnostic criteria for shock: 1, there are causes that induce shock 2, impaired consciousness 3, fine and rapid pulse 4, wet and cold extremities, florid spots, pale mucous membranes, urine volume less than 30 ml, systolic blood pressure less than 80 mm Hg injection, and pulse pressure difference less than 20 mm Hg injection. The treatment of shock is traditionally based on blood pressure, heart rate, and urine output, but in fact many patients’ organs are still hypoperfused and there is still inadequate tissue oxygenation, so patients still have a high mortality rate if they do not continue to deal with shock at this time. Endpoints of resuscitation in recent years include evaluation of blood lactate concentration, degree of base deficiency, intestinal mucosal PH, oxygen transport index, arterial and venous partial pressure of oxygen and oxygen saturation measurements.