Endometrioid adenocarcinoma is a malignant tumor that occurs in endometrial epithelial cells and is commonly seen in postmenopausal women. Endometrioid adenocarcinoma is a malignant tumor in gynecology that is prone to infiltrative growth and cancer metastasis, so early detection and treatment with early surgery is the key to treatment. Endometrioid adenocarcinoma is mainly due to the abnormal proliferation of endometrial epithelial cells. This cancer can also be divided into highly differentiated adenocarcinoma, moderately differentiated adenocarcinoma and poorly differentiated adenocarcinoma, with highly differentiated adenocarcinoma being less malignant. Some women with endometrioid adenocarcinoma have abnormal menstruation and thick endometrium, and the pathology after scraping indicates atypical hyperplasia or cancer of endometrium; or some women have menstruation again after several years of menopause, which indicates thick endometrium, and the pathology after scraping indicates atypical hyperplasia or cancer of endometrium, and some are diagnosed after hysterectomy. In conclusion, endometrioid adenocarcinoma is a kind of malignant tumor in gynecology, and if the cancer spreads or metastasizes, it will directly threaten the patient’s life, so if it can be detected and treated as early as possible and operated as early as possible, the combination of chemotherapy and radiotherapy after surgery can greatly improve the patient’s quality of life. Of course, it is also important to maintain a good attitude, establish confidence in overcoming the disease and have good living habits for the treatment of the disease.