Combining Adapalene Gel and Azelaic Acid Cream is generally not recommended, and if combination is needed, a physician or pharmacist should be consulted first to avoid the risk of combination. Adapalene Gel is an anti-acne medication that is used primarily for common types of acne on the face, chest and back characterized by pimples, papules and pustules. Adapalene is a retinoid compound, and common adverse reactions such as itching, tingling, and erythema can occur during the initial phase of treatment with Adapalene Gel. Sunlight and ultraviolet rays can also cause localized irritation reactions in the skin, so when using it, try to use it before going to bed, and also avoid combining it with other medications, especially dermatologic medications which may also interact with each other. In addition, Adapalene Gel should not be used in patients with severe acne, or in patients using other vitamin A-acids or “waxing” methods of hair removal. Azelaic acid cream is a common dermatologic agent used primarily for the topical treatment of mild to moderate inflammatory acne vulgaris, such as rosacea. Adverse reactions include erythema, dry skin, flaking, etc. It is contraindicated for those who are allergic to the ingredients of azelaic acid cream, and it is important to pay attention to not sealing the bag when using the medicine. Azelaic acid cream is a prescription drug, its exact mechanism of action is still unknown, and the simultaneous use of other drugs may occur drug interactions, should follow the doctor’s instructions to standardize the use. Adapalene gel and azelaic acid cream are not recommended to be used together, so as not to cause severe local irritation, aggravate the disease, the specific use of medical advice.