Hidden pain in liver area with weakness may be caused by hepatitis, cirrhosis, cholecystitis, gallbladder stones, hepatobiliary tumors and other liver and gallbladder diseases, and it is recommended that the patient actively consult a doctor for a clear diagnosis. 1. Hepatitis: usually caused by viral and bacterial infections or alcoholism, liver cell damage and liver function decline. Common symptoms of hepatitis are loss of appetite, nausea, vomiting, vague pain in liver area, jaundice, fever and other symptoms. 2. Cirrhosis: due to hepatitis virus infection, alcoholism, drugs and other factors, the liver has diffuse fibrosis, the tissue has been severely damaged to form pseudo lobe, usually manifested as lethargy, fatigue, loss of appetite, jaundice, gums or nosebleeds, edema of both lower limbs and other symptoms, may also appear in the liver area pain. 3. Cholecystitis: cholecystitis is mostly due to gallbladder stones and bacterial infection, which can be characterized by pain in the right upper abdomen, fever, nausea and vomiting, and fatigue. 4. Gallbladder stones: high-fat diet, taking contraceptive pills and other factors may induce gallbladder stones, most of them are asymptomatic, typical symptoms are paroxysmal colic pain in the upper abdomen, accompanied by nausea and vomiting, etc., which may also cause symptoms of fatigue. 5. Hepatobiliary tumors: including hepatocellular carcinoma, gallbladder carcinoma, cholangiocarcinoma, which may also cause symptoms of lethargy, fatigue and pain in liver area. Generally speaking, surgery is the first choice for tumor treatment, but it is still necessary for doctors to analyze whether surgery is possible according to the patient’s own condition. In addition, pain in liver area with fatigue may also be seen in right heart failure, lobar pneumonia and other diseases of other organs. It is recommended to go to the hospital in time to clarify the cause of the disease, under the guidance of the doctor for treatment.