Inflammation of the wisdom tooth is usually an inflammation of the soft tissue surrounding the wisdom tooth, which is called pericoronitis. Once wisdom tooth pericoronitis occurs, it must be treated promptly with anti-inflammatory treatment. The wisdom tooth should be removed as soon as possible after the inflammation is eliminated, otherwise, pericoronitis will occur repeatedly. Wisdom teeth tend to grow at the end of the row of teeth, and most of them are blocked because the row of teeth is narrow. Once an obstructed wisdom tooth is present, it will form a blind pocket with the surrounding soft tissue, which can accumulate bacteria and cause pericoronitis easily. When pericoronitis occurs, there is significant swelling and pain, as well as interstitial infection, restricted mouth opening, and systemic symptoms. The best treatment for pericoronitis is anti-inflammatory therapy. Oral anti-inflammatory drugs such as roxithromycin and metronidazole can be taken. More importantly, a local rinse with 3% hydrogen peroxide and saline can be done alternately to remove the dirt and pus from the blind pocket, and then iodine glycerin can be applied to the area for anti-inflammatory purposes. The wisdom tooth pericoronitis will recover in about a week. Once the wisdom tooth pericoronitis has healed and is no longer swollen or painful, the wisdom tooth should be extracted in a timely manner. For pain caused by inflammation of the wisdom tooth nerve due to tooth decay, the wisdom tooth should also be extracted as soon as possible after the acute inflammation period has subsided. Because wisdom teeth are too far back in the mouth, it is extremely difficult to fill or “kill the nerve” treatment, only a few orthodontic teeth with occlusion with the wisdom teeth above can try to retain after treatment. Prophylactic extraction of blocked wisdom teeth is necessary to help prevent pericoronitis.