Hard lumps on thighs may be lipoma, sebaceous cyst or neurofibroma, etc. If there is redness, swelling and pain, etc., it means that it is caused by local inflammation, and there is also the possibility of malignant tumors such as soft tissue sarcoma. 1. If the edge of the hard lump is clear and can be rolled, there is no pressure and pain, not red and not swollen, generally suggests that it is lipoma, sebaceous cyst, neurofibroma, either one is benign, if it does not affect the aesthetic appearance, there is no need for special treatment, and the hard lump grows up gradually or is accompanied by pain and other discomforts, it is necessary to carry out surgical treatment. 2. If the hard lumps have pain, redness, swelling, ulcers and other inflammatory changes caused by inflammation, it is recommended to take oral and topical antibiotics, commonly used topical drugs such as ichthyolite, erythromycin ointment, etc., and oral medication can be used with amoxicillin, erythromycin, and other broad-spectrum antibiotics. 3. Thigh if there is a soft tissue sarcoma and other malignant tumors may also be manifested as hard lumps, generally need to be diagnosed by pathology after surgery, usually also need to perform chemotherapy, targeted therapy and other comprehensive treatment after surgery. There may be other reasons for the hard lumps on the thighs, and it is recommended to go to the hospital in time to clarify the cause of the disease and standardize the treatment according to the doctor’s instructions.