Craniofacial malformations include craniosynostosis, atlanto-occipital malformation, congenital hydrocephalus, macrosomia, etc. The causes vary depending on the disease, and mainly include developmental disorders, vitamin D deficiency, and genetic factors. 1. Stenosis: It may be caused by embryonic mesodermal developmental disorders, ectopic ossification centers in the membranous tissues of the bone sutures, vitamin D deficiency, and hyperthyroidism. 2. Atlanto-occipital malformation: it may be caused by congenital developmental bony malformation of the posterior cranial fossa and atlantoaxial spine. 3. Congenital hydrocephalus: it may be caused by excessive generation of cerebrospinal fluid (CSF) due to ventricular choroidal adenoma, and impaired absorption of CSF due to meningitis, subarachnoid hemorrhage, and venous sinus thrombosis. 4. Megalencephaly: It may be caused by mutation of NSD1 gene on 5q35, familial Sotos syndrome, autosomal dominant genetic malformation. If you have or suspect cranioencephalic malformations, it is recommended to go to the hospital in time in order to avoid delaying the condition.