Patients with calf peroneal vein and intermuscular vein thrombosis should be treated with rest and braking, medication or interventional therapy under the guidance of doctors according to their conditions. 1. Resting and braking: after discovering calf DVT, lower limbs should be braked immediately and bed rest should be taken to prevent thrombus from dislodging, which may lead to embolism of important organs, and the peripheral blood circulation of lower limbs should be closely observed. 2. Drug therapy: anticoagulant therapy can be used after exclusion of contraindications. Use anticoagulant drugs as prescribed by doctor, such as subcutaneous injection of low molecular weight heparin, intravenous urokinase and other thrombolytic agents, oral warfarin or rivaroxaban, etc., and observe whether there is any bleeding in the whole body during the period of using drugs. 3. Interventional therapy: If the condition is serious or the effect of conservative treatment is not good, interventional therapy can be adopted, including direct thrombolysis through catheter and implantation of inferior vena cava filter. Patients with calf peroneal vein and intermuscular vein thrombosis should actively cooperate with doctors for examination and standardized treatment, and the specific treatment plan should be determined according to the condition after evaluation by professional doctors.