Drinking coffee after drinking alcohol is not recommended and may be extremely taxing on the body, and may also present dangers such as acute illness. The ethanol in alcohol and the caffeine in coffee both have an excitatory effect, and drinking both at the same time for a short period of time can lead to extreme excitation of the body’s nervous system, which can be particularly harmful to the heart and brain. In mild cases, dizziness, headache, palpitations may occur, and in severe cases, various cardiac arrhythmias may occur. Drinking coffee after drinking alcohol is not conducive to gastric metabolism and may also irritate the mucous membrane of the stomach, leading to nausea and vomiting. It may also cause excessive secretion of gastric acid, or even massive reflux, leading to a higher incidence of erosive gastritis and, in severe cases, gastrointestinal bleeding. Considering the human health perspective, drinking alcohol is harmful to your health, and not drinking alcohol is the most fundamental way to minimize alcohol damage to your body.