Nitroglycerin chest pain, can be seen in a variety of cases, different cases of different treatment methods. 1. The chest pain after taking nitroglycerin can be seen in acute infarction, variant angina pectoris, reflux esophagitis, aortic coarctation and other diseases. 2. If it is caused by acute myocardial infarction, thrombolysis or interventional therapy can be given. 3. In case of variant angina pectoris, calcium antagonists such as nifedipine may be given. 4. In case of acute reflux esophagitis, proton pump inhibitors or H2 receptor antagonists can be given. 5. If it is aortic coarctation, it is feasible to have interventional endoluminal isolation or open thoracic surgery. Warm reminder: coronary heart disease patients oral nitroglycerin is ineffective, need to consult a doctor in a timely manner, according to the physician’s diagnosis, targeted treatment.