Guillain-Barre generally refers to Guillain-Barre syndrome, which may be painful during the recovery period of Guillain-Barre syndrome and may gradually disappear as the condition recovers further. Guillain-Barre syndrome is an autoimmune peripheral neuropathy, and patients may experience decreased muscle strength, decreased sensory sensitivity, as well as low back, lumbosacral pain, and gastrocnemius pressor pain. Therefore, patients may also experience pain during the recovery period, but as time progresses and the disease gradually recovers, the patient’s pain symptoms may disappear on their own. However, if the patient has localized pain for a long period of time and the symptoms worsen, accompanied by bilateral peripheral facial paralysis, as well as hoarseness and dysphagia with damage to the glossopharyngeal nerve, it is mostly considered to be due to the exacerbation of the disease. If localized pain persists during the recovery period, it is recommended to report to the doctor in time and actively cooperate with the doctor to take relevant treatment measures, so as to avoid delaying the condition and damaging the health.