Wrist swelling, rheumatoid factor negative does not completely exclude rheumatoid arthritis, in addition to wrist swelling may also be associated with tenosynovitis, carpal tunnel syndrome and other diseases, the specific combination of the patient’s other clinical symptoms as well as examination. 1. Rheumatoid arthritis: rheumatoid arthritis involving the wrist joint may lead to joint swelling, pain and other symptoms, not every case of rheumatoid arthritis patients have a positive rheumatoid factor, rheumatoid factor can not be completely excluded from the negative rheumatoid arthritis, but also need to be combined with the X-ray, clinical symptoms, medical history and other factors for comprehensive analysis. 2. Tenosynovitis: tenosynovitis is common in middle-aged and old women, often involving tendons and tendon sheaths, resulting in joint pain and tenderness. 3. Carpal Tunnel Syndrome: Carpal Tunnel Syndrome is a peripheral nerve entrapment syndrome, when the nerve in the carpal tunnel is compressed, it may lead to numbness, pain in the fingers and swelling of the wrist. Rheumatoid factor normal patients with wrist swelling may have other reasons, it is recommended that patients go to the hospital in a timely manner, under the guidance of the doctor for diagnosis and treatment.