You should not have sex while on interferon medication after HPV infection. Sexual intercourse may cause the medicine to be discharged thus reducing the therapeutic effect, and may also cause the virus to infect the sexual partner. 1. Reduce the therapeutic effect: interferon belongs to the immunomodulators, used in the treatment of viral diseases and certain malignant tumors. Adverse reactions commonly include fever, fatigue, headache, arthralgia, loss of appetite, etc.; interferon is contraindicated for those who are allergic to interferon, have a history of severe cardiovascular disease, those who can not tolerate the side effects, epileptic patients and those who have disorders of the central nervous system. Interferon medication, you need to clean the vulva every night after the interferon gel will be pushed to the cervix, sexual life may make the medicine from the vagina, reduce the efficacy. 2. Infection of sexual partners: human papillomavirus is mainly transmitted through sexual contact, genital mucous membrane damage during sexual intercourse, there will be a risk of viral infection of sexual partners. Therefore, HPV infection should be avoided during treatment with interferon, and should be reviewed after three months of treatment. Patients should follow the doctor’s instructions for standardized treatment and regular follow-up.