The common pathogens of upper respiratory tract infections are bacteria, viruses, mycoplasma or bacteria combined with viruses, and bacteria combined with mycoplasma infections. Common bacteria include Staphylococcus aureus and Streptococcus pneumoniae; viral infections are most commonly known as the common cold virus, as well as influenza A and B viruses, and EBV; mycoplasma is a pathogen between bacteria and viruses, which also easily invades the upper respiratory tract and causes inflammation. Upper respiratory tract infection is what is usually called a cold. The initial stage of a cold is mainly a viral infection, manifested as nasal congestion, runny nose, fever and cough. In the early stage without timely treatment, the disease develops further and it is easy to combine with bacterial infections, and the symptoms are more serious when combined with infections, so we should pay attention to standardized treatment and reasonable care, especially during the flu, we should pay attention to isolation.