Soreness in the palm of the hand is usually caused by certain diseases, such as hand strain, stenosing tenosynovitis, rheumatoid arthritis and so on. 1. Hand strain: If the hand is overused for a long period of time, it may cause strain on the muscles, joints and ligaments of the hand, which will lead to the symptom of soreness in the palm of the hand, which can be relieved after resting. 2. Tendovaginitis: Long-term excessive friction between tendons and tendon sheaths may cause tendovaginitis, which manifests itself as localized swelling, pain, and restriction of activities, as well as tightness and pain in the palm of the hand when making a fist. 3. Rheumatoid arthritis: due to autoimmune, genetic, infection and other factors lead to rheumatoid arthritis, which in turn cause patients with synovial membrane damage to the joints, appearing hand joints, stiffness, difficulty in making a fist and other manifestations. In addition to the above reasons, trauma, gout, etc. may also cause symptoms of soreness in the palm of the hand. If you have soreness in the palm of your hand, it is recommended that you consult a doctor in time to identify the cause of the condition and get the appropriate treatment.