Since 2014, our center has achieved a good clinical pregnancy rate with the modified extra-long regimen for recurrent fertility failure, endometriosis ovarian chocolate cysts, myometriosis, uterine fibroids, and endometrial thinning, and the pregnancy rate has increased significantly compared to the previous ones. The specific implementation of the modified ultra-long regimen: in general, 2.5mg or 1.5mg or 3.75mg (the exact dose depends on the size of endometriosis or fibroids) of Dafylline is injected intramuscularly on the 2nd-3rd days of menstruation, and then Dafylline 1.5mg or 1.25mg is injected again at the hospital after 28 days. Some patients will not have their period after the first Dafirin injection, some patients will not have their period after the second Dafirin injection, in any case, it does not matter whether they have their period or not, and it does not have any effect on them. After 14-18 days after the second Dalfylline injection, the cycle starts with ovulation. Ovulation will take about 10-12 days of continuous injections for egg retrieval. Some patients ask what is the difference between 14 days and 18 days after the second Dalfylline injection. In fact, there is basically no difference from the point of view of pregnancy rate, the only difference is that the start on day 14 may be 1-2 shots more than the start on day 18. The modified extra-long protocol can also be used for frozen embryo transfer. The specific method is the same as above, except that starting 14-18 days after the second Dalfylline injection, instead of ovulation promotion, oral supplementation is given, specifically: 2 tablets of supplementation each night for 5 days, then 2 tablets in the morning and 2 tablets in the evening for 5 days (i.e. 4 tablets per day), then 2 tablets in the morning and 2 tablets in the evening for 3 days (i.e. 6 tablets per day), after which you will need to come in for an ultrasound to check the endometrium and, if necessary, have blood drawn for endocrine hormones. The above mentioned Daphylline injection, if not 3.75mg, but 2.5mg, 1.5mg, 1.25mg are available for several people to share 1 shot, which can reduce the cost per patient. Because a full dose of Daphylline is 3.75mg and the price is 1772 RMB, if each patient needs to inject 1.5mg, then 2 patients can use one, so the cost can be reduced by half. That’s why our center often allows patients to come in and make an appointment for a carpool injection. For example, if you have your period today, then you can call or leave a message for me today saying that I have my period today and need to make an appointment for Duffylline, then we can register you for a Duffylline carpool injection. Of course, this is only possible if we have helped you develop a modified extra-long protocol first. This appointment requires you to come to the hospital for an appointment when you have your period, or on the 2nd-3rd day of your period, and sometimes you need to have an ultrasound to rule out any remaining large follicles in your ovaries bilaterally. Many patients ask what exactly are the benefits of the modified ultra-long protocol. First of all, we need to clarify the role of Dafylline. Duffylline is a descending regulatory drug that acts on the human hypothalamus so that the hypothalamus no longer sends out hormonal signals that promote follicle development, then the pituitary gland and ovaries will no longer have dominant follicle development and both ovaries will be in a very quiet, calm state, which means they will rest well and the endometrium will be very thin. Generally, 14 days after Dafylline injection, the full down-regulation effect can be achieved, and the effect will disappear after 28 days. Two dalfylline downregulations are very effective in relieving endometriosis and shrinking fibroids. After 2 dalfylline injections, the uterus and bilateral ovaries will also return to their very initial state, which, to give a less appropriate example, is like a computer that has regained its original vitality after a system reinstallation. At this time, initiation of ovulation treatment or preparation of the lining with Tocopherol will yield excellent results. The follicles will generally grow well and uniformly, and the lining will grow well without further unevenness, so the modified extra-long protocol is associated with a high clinical pregnancy rate both for fresh egg retrieval cycles and for frozen embryo transfer. In patients with recurrent failure of implantation, the modified extra-long protocol + blastocyst transfer can significantly increase the clinical pregnancy rate, which has been confirmed in clinical practice. The modified extra-long protocol can be used in the majority of patients, but patients with extremely low ovarian reserve and too few follicles are not suitable for the modified extra-long protocol.