Gastroesophagitis is considered as gastritis and esophagitis. H. pylori quadruple therapy can treat gastritis and esophagitis caused by H. pylori infection. H. pylori quadruple therapy includes common medications such as acid-suppressing drugs like omeprazole and rabeprazole; antibiotics such as amoxicillin, metronidazole, and clarithromycin; and medications to protect the gastric mucosa such as bismuth potassium citrate and colloidal bismuth pectin. The above drugs may cause allergies, indigestion, nausea, vomiting, diarrhea and other side effects. Through the cooperation of the above drugs, it can kill Helicobacter pylori, so it can be used to treat gastritis and esophagitis caused by Helicobacter pylori infection. The acid-suppressing drugs and the drugs to protect the gastric mucosa in them are also effective in gastritis and esophagitis caused by drugs, diet, alcohol consumption and heredity. But antibiotics are not recommended when there is no H. pylori infection. To summarize H. pylori quadruple drug, it can treat gastritis and esophagitis. However, it is recommended to take medication under the guidance of a doctor for treatment, and it is not recommended to take medication on your own.