Lipoprotein phospholipase A2 of 255 μg/L is serious if it is accompanied by high blood lipids and myocardial ischemia; if it is not accompanied by these problems, the problem is not serious. Lipoprotein phospholipase A2 can reflect the severity of atherosclerotic lesions to a certain extent, and higher values generally mean that the patient is at greater risk of developing atherosclerosis. The normal value of Lipoprotein phospholipase A2 is between 131~376 μg/L for men and 120~342 μg/L for women, but different hospitals use different reagents and diagnostic criteria, so you need to refer to the hospital’s test index. Therefore, lipoprotein phospholipase A2 of 255μg/L is generally in the normal value, but whether it is serious or not needs to be combined with the results of blood lipid examination and electrocardiogram. If the patient is found to have high blood lipids, myocardial ischemia on electrocardiogram, or if the patient has angina pectoris, chest tightness, panic and other physical discomforts, it means that the patient’s condition is serious and it is recommended that the patient should undergo timely lipid control treatment with statins such as simvastatin, lovastatin, resuvastatin and other treatments. If other indicators are normal, then the patient’s condition is not serious and can be maintained by maintaining a light diet, eating less pork, beef and mutton, not eating animal offal, consuming chicken, duck, fish and meat as appropriate, eating more fresh vegetables and fruits, and exercising more to maintain good health. When the lipoprotein phospholipase A2 reaches 255μg/L, it is important to follow the doctor’s advice for further examination, and follow the doctor’s advice for treatment or life modification.