Eszopiclone and dexzopiclone are both sedative and sleeping drugs, the difference is that the mechanism of action, side effects of both eszopiclone and dexzopiclone are different. Eszopiclone is a medium-acting benzodiazepine drug, mainly used for sleep maintenance difficulties, easy to wake up patients, the drug has a better anti-inflammatory effect Eszopiclone tablets common adverse reactions are dry mouth, drowsiness, dizziness and so on. Long-term use may also occur ataxia and tremor. Rash and leukopenia may also occur in a very small percentage of patients. Dexzopiclone is a new non-benzodiazepine hypnotic drug that can be used in various types of insomnia, especially for patients who stay awake the next morning, this drug can be preferred. The main adverse effects include bitter mouth, dizziness, drowsiness, weakness, nausea and vomiting. This drug is contraindicated in patients with respiratory insufficiency, myasthenia gravis, and severe sleep apnea syndrome. Patients can choose the suitable medication for treatment according to their own conditions under the advice of doctors. Do not blindly self-medicate to avoid adverse reactions.