The corners of the mouth on both sides of the black is common in keratitis, hormone side effects and drug rash, etc., the main drug treatment and surgical treatment. 1. Keratitis due to the corners of the mouth area skin mucous membrane cracks, vesicles, scabs lead to the corners of the mouth localized melanin deposits, manifested as the corners of the mouth black. After a long time of metabolism can be self-healing, but also through local laser treatment and other surgical methods of treatment. 2. When applying glucocorticoid drugs externally, its side effects can also lead to melanin deposition, resulting in the corners of the mouth blackened, at this time you need to stop using drugs. 3. Drug rashes can also lead to melanin deposition at the corners of the mouth, such as taking sulfa drugs, the skin around the corners of the mouth black and itchy, after stopping the drug melanin can be absorbed, dissipated, the symptoms can be improved. At the same time hydrocortisone, loratadine and other therapeutic drugs, can also improve the other symptoms brought about by drug rash. If you find the corners of the mouth black, you should seek medical attention in time, under the guidance of the doctor’s treatment, not unauthorized use of medication, so as not to delay the condition. Pay attention to the skin care around the mouth, eat less spicy food, and maintain a regular routine.