Linaclotide is not recommended for long-term use. Long-term use of linaclotide may result in adverse effects such as drug resistance and drug overdose. Linaclotide is a guanylate cyclase agonist, which is suitable for the treatment of constipated irritable bowel syndrome in adults, but the drug should be discontinued in time when the condition is under control and the efficacy is consolidated. Blindly taking it for a long period of time may cause the body’s sensitivity to the drug to be reduced, produce drug resistance, or cause symptoms of drug overdose (such as diarrhea, etc.), so it should not be taken for a long period of time. It should also be noted that linaclotide can generally be observed after 1 week of medication, if the symptoms do not improve after 4 weeks of treatment, the need to continue treatment should be reassessed under the guidance of a doctor. Linaclotide is contraindicated in people who are allergic to it, known or suspected to suffer from mechanical intestinal obstruction, and adverse reactions such as abdominal pain and bloating may also occur during administration. This drug must be used strictly under the supervision of a physician, and should not be used blindly for long periods of time in large quantities to avoid adverse consequences.