Children with Down syndrome all look the same, mainly because the disease is associated with chromosomal abnormalities, so children with the disease can have similar facial features. Down syndrome, also known as trisomy 21, is caused by an abnormality of chromosome 21 when the fertilized egg divides to form a human individual, resulting in the presence of an extra chromosome 21 in the embryo’s somatic cells. Because it is a chromosomal disorder, children with trisomy 21 have similar facial features, such as small eyelid slits, wide eye spacing, upward slanting of the outer canthus of both eyes, low nasal bridge, and small outer ears. If an infant or child has these special features, he or she should go to the hospital in time. Both the parents and the child need to undergo a karyotype test to determine whether he or she has Down’s syndrome. Pregnant women should pay attention to prenatal checkups during pregnancy, actively listen to the advice of professional doctors to do a comprehensive care and health care work, if found fetal malformation, it is recommended to go to the regular hospital as soon as possible to do eugenics counseling, and follow the doctor’s advice for treatment.