Glutaminase exists in various cells, especially in hepatocytes, followed by cardiomyocytes, and the normal reference value is 0-40 U/L. 300+ glutaminase indicates that it may be related to hepatocyte damage caused by liver diseases, gallstones, drugs and poisons. 1. Liver disease: under normal conditions, only a small amount of glutamine is released into the blood. When liver cells are attacked and destroyed, glutamine is released from the liver cells into the blood, causing its concentration in the blood to rise. Such as viral hepatitis, cirrhosis, toxic hepatitis, primary and metastatic hepatocellular carcinoma. 2. Cholelithiasis: i.e. stone formation in gallbladder and bile ducts, manifested by biliary colic, nausea, vomiting, which may be accompanied by jaundice, chills and high fever, loss of appetite, etc., and the alanine aminotransferase will be elevated in general. 3. Drugs and poisons: such as chlorpromazine, isoniazid, quinine, salicylic acid preparations, ampicillin and carbon tetrachloride, organophosphorus, etc., can lead to elevated ghrelin. There are many other causes of elevated ghrelin, such as alcoholism and diabetes. It is recommended to consult a doctor in time to clarify the diagnosis and carry out targeted treatment.