The occurrence of cranial defects firstly affects the aesthetic appearance of the patient’s head; in addition, the soft tissues inside the skull lack the protection of the hard shell and may be easily damaged by external forces; secondly, cranial defects cause the instability of intracranial pressure, which also affects the normal operation of intracranial life activities. The external manifestation is that it may lead to frequent headache and dizziness, in addition to the patient’s fear of pulsation, expansion and collapse of the defect area, as well as fear of sunlight, vibration and even noisy sound. It may also cause lack of concentration and memory loss, and some patients show depression, fatigue, reticence and low self-esteem. Therefore, it is necessary to have skull repair surgery in time after skull defect. Many patients would like to know the procedure of skull repair. The detailed steps of skull repair surgery: first anesthesia, disinfection, then scalp incision, exposure of the bone window, preoperative three-dimensional shaped polyetheretherketone PEEK repair piece, according to the shape of the patient’s skull defect adjustment reset and fixed, suture the scalp, surgery is completed. It is necessary to emphasize that not only is it important to standardize the correct detailed steps of cranial repair surgery, but also the cranial repair material is important. Clinically, the current repair material used for cranial repair is peek cranial repair. peek material can be shaped in three dimensions according to the patient’s cranial data and highly restore the anatomical structure of the cranium, in addition, its performance in elasticity, hardness, heat insulation, stability and other aspects is basically the same as the autologous cranial bone, there is no rejection, and it will not interfere with CT, MRI and other examinations, so it has become the new favorite in the cranial repair world.