One semen test is usually not able to completely determine sperm malformation, and multiple tests should be conducted to finally confirm the diagnosis; if sperm malformation is detected in multiple tests, the cause should be identified and treated at the earliest possible time. Sperm deformities are related to a variety of factors such as dietary habits, medications, low hormone levels, physical injuries, inflammation and micronutrient deficiencies. The result of one semen analysis is not enough to confirm the diagnosis. Generally speaking, at least three semen collections and examinations, as well as genetic tests, endocrine tests, imaging tests, etc., should be conducted in order to confirm the diagnosis finally. Patients are advised to actively cooperate with their doctors for examination and final diagnosis by their doctors. If the diagnosis of sperm abnormality is confirmed, it is necessary to go to a regular hospital in time to identify the cause of the disease and follow the doctor’s instructions for treatment.