Vaginal insertion is usually possible 12 hours after sex, but under the guidance of a doctor to use the medication reasonably, and then avoid coitus during the medication. Women who have gynecological infections that need to be treated with antibiotics are usually not allowed to have sex, as the disease may be contagious and not be cured for a long time. Vaginal insertion of drugs 12 hours after sex is also therapeutic, but the efficacy of the drug may vary. Therefore, it is recommended that women in the treatment of gynecological diseases need to plug the situation to avoid sexual intercourse, usually keep the vulva clean, if you need to use drugs should be under the guidance of the doctor for reasonable use, to avoid other serious problems.