Tumor at the junction of cystic duct and common bile duct belongs to middle-stage cholangiocarcinoma, which is mainly treated by tumor resection + common hepatic duct-jejunum anastomosis or palliative surgery. According to the site of tumor growth, cholangiocarcinoma is divided into upper, middle and lower cholangiocarcinoma, and middle cholangiocarcinoma is located in the opening of the cystic duct to the upper duodenum, which accounts for 10%~25%. Chemotherapy and radiotherapy do not have certain effect on the treatment of cholangiocarcinoma, and radical resection should be pursued. Surgical methods for cholangiocarcinoma in different growth areas are also different. The main surgical methods for mid-stage cholangiocarcinoma are: resection of tumor and bile ducts more than 0.5cm away from the edge of the tumor, “choroidalization” of hepatic-duodenal ligament, and common hepatic duct-jejunum Roux-en-Y anastomosis. When cholangiocarcinoma patients cannot be resected, palliative surgery can be adopted, such as percutaneous hepatic puncture biliary drainage or placement of endoprosthesis, choledocho-jejunal anastomosis, etc., to improve the quality of patient’s survival. The choice of treatment strategy for cholangiocarcinoma should be under the guidance of specialized doctors.