After the hormone level drops to the normal range after down regulation, it means that the down regulation is successful, and the menstrual cycle will return to normal and regular, during the period of down regulation, it is recommended to check the hormone six regularly, according to the level of the hormone six to determine whether to stop using the medication. Down-regulation generally refers to the use of estrogen-progestin sequential therapy to regulate endocrine level imbalance, endocrine imbalance will occur in menstrual disorders, ovulation and other symptoms, down-regulation after the success of menstrual regularity, return to normal ovulation phenomenon. During the period of down-regulation, it is recommended to relax, keep a good mindset, and regularly review the six hormone tests to determine the changes in hormone levels. If the hormone levels are within the normal range, and the menstruation is regular, and normal ovulation resumes, it means that the down-regulation is successful, and the medication can be discontinued, and if there is a requirement for fertility, the preparation for pregnancy can be carried out in the next menstruation cycle after discontinuation of the medication.