The common causes of particularly itchy toes at night include tinea pedis, eczema, scabies, etc. It is necessary to clarify the specific cause of the disease and then take the appropriate medication, such as ketoconazole, terbinafine, loratadine, etc., for treatment. 1. Tinea pedis: this disease is mainly caused by fungal infections, which can be characterized by itching of the feet, aggravated at night. Treatment, can be used externally antifungal treatment, such as ketoconazole ointment, terbinafine cream, etc.; lesions in a larger range, oral antifungal treatment, such as terbinafine, itraconazole, etc.; secondary bacterial infections, but also the use of antibiotics, such as erythromycin and so on. 2. Eczema: the cause of this disease is unknown, but if the skin of the foot is in contact with irritating substances, such as pollen, dust, soap, etc., this disease can be induced, appearing foot itching, aggravated by the symptoms at night. For treatment, topical glucocorticoid therapy, such as hydrocortisone cream, dexamethasone ointment, etc.; oral antihistamine therapy, such as loratadine, cetirizine and so on. 3. Scabies: Scabies is mainly caused by the scabies mite parasitized in the epidermis of human skin. When the foot skin has scabies mite parasitism, usually there will be foot itching, aggravated at night. It can be treated with topical sulfur ointment, etc.; oral antihistamine treatment, such as loratadine, cetirizine, etc.; oral antiparasitic drug treatment, such as ivermectin, thiabendazole, etc.. It is recommended that patients go to a regular hospital, under the guidance of the doctor’s reasonable medication, not blindly self-medication, to avoid delaying the condition.