The oozing of pleural effusion after puncture and drainage and extraction of tube can be treated by conservative treatment and surgical treatment. 1. Conservative treatment: patients with pleural effusion after puncture and drainage tube extraction oozing, need to regular drainage tube orifice change, if necessary, under the guidance of the doctor to take antibiotics such as roxithromycin, amoxicillin and so on to prevent infection. Because the drainage tube causes a direct channel between the chest cavity and the outside world, it can ooze along the channel after the tube is removed, and the patients try to keep the affected side in a high position in their daily life, enhance nutrition and promote the absorption of pleural effusion. 2. Surgical treatment: if there is still a large amount of exudate after puncture and drainage of pleural effusion and extubation with regular medication change and nursing care, repeated thoracentesis can be adopted to puncture and extract the fluid in the pleural cavity, and at the same time to find out the cause of large amount of exudate, and treat the cause in a timely manner. It is recommended that the patient choose the correct treatment plan under the advice of the doctor, and always observe the physical condition.