Chest tightness, nausea and vomiting are usually caused by gastrointestinal diseases, including gastrointestinal cold, gastritis, peptic ulcer, or heart diseases, diabetic ketoacidosis and other factors, which need to be improved with relevant examinations to clarify the causes and then treated according to different causes. I. Gastrointestinal diseases 1. Gastrointestinal flu: Gastrointestinal dysfunction caused by viral infection, accompanied by chest tightness, nausea and desire to vomit. Treatment should focus on rest, reduce physical exertion, fully replenish nutrients to enhance the body’s immunity, follow medical advice to rehydration, antidiarrheal treatment to maintain the body’s water and electrolyte balance; 2, gastritis: cold, unclean diet, spicy food to stimulate the gastric mucosa or lead to stomach cramps, nausea, vomiting performance can occur, some patients also accompanied by chest tightness symptoms. Pay attention to dietary hygiene, avoid eating too much greasy, hard, spicy and irritating food, pay attention to keeping warm, and use drugs that inhibit gastric acid secretion, gastric mucosal protective agents and promote gastrointestinal motility to improve symptoms under the guidance of doctors; 3. Peptic ulcer: inflammatory reaction, necrosis and detachment of the mucosa of the gastrointestinal tract, forming ulcers, and the ulcer surface can be stimulated with symptoms of chest tightness, nausea and vomiting. Medical advice to use drugs to reduce stomach acid, promote gastric power, enhance the protection of gastric mucosa. Heart disease 1. Acute left heart failure: During the attack, chest tightness is caused by difficulty in breathing, and painful stimulation can lead to nausea and vomiting. Treatment can follow medical advice to use diuretics, vasodilators, etc. to enhance myocardial contractility and reduce cardiac load, thus relieving symptoms; 2. Acute inferior wall or right ventricular myocardial infarction: myocardial ischemia can lead to pain in the precordial region, chest tightness and dizziness, causing abnormal manifestations of nausea and vomiting. Treatment should pay attention to bed rest, and drugs such as nitroglycerin, metoprolol and bisoprolol can be applied to dilate coronary arteries and reduce myocardial oxygen consumption, or to relieve symptoms through interventional surgery or thrombolysis. Third, diabetic ketoacidosis due to hyperglycemia, high blood ketones, metabolic acidosis, patients may have symptoms of dyspnea, chest tightness, nausea, and desire to vomit, and should be rehydrated as soon as possible to restore blood volume, correct water loss, apply insulin to lower blood sugar, correct electrolyte and acid-base balance imbalance, and at the same time actively search for and eliminate causative factors to prevent and treat complications and reduce the morbidity and mortality rate.