Toe thumb nail empty, and there is blood and water out of the possible causes for bacterial infection caused by onychomycosis, often caused by Staphylococcus aureus. It is usually treated with medication and antibacterial therapy, and surgery if necessary. Inguguinitis is a purulent bacterial infection of the skin along both sides of the nail to form a nail groove and the surrounding tissue. Often occurs first in one side of the nail groove subcutaneous, manifested as redness, swelling, heat and pain, pus after the nail groove subcutaneous white pus spots, fluctuating feeling. Deeper spread to subungual abscesses can lead to rupture of the subungual musculature with pus and blood. This condition, which is also seen in trauma to the thumb on the foot, such as stepping on it, can result in subnail bruising. Bruising that extends beyond the edge of the nail can lead to squeezing with blood flowing out. The occurrence of foot thumb nail empty, squeeze blood this situation, need to go to the hospital in a timely manner, follow the doctor’s instructions for treatment.