For appendicitis, surgery is the main treatment, and anti-inflammatory drugs can be used in combination to promote the absorption of inflammation, help relieve abdominal pain and control infection. Commonly used oral anti-inflammatory drugs for appendicitis patients include levofloxacin, metronidazole, ornidazole, cefixime, gentamicin, etc. It is clinically believed that once appendicitis is diagnosed, the best treatment plan should be selected by combining the patient’s symptoms and signs as well as imaging examinations to eliminate the patient’s symptoms within a short period of time, reduce the patient’s pain, and minimize the treatment time and cost, and the majority of patients with appendicitis require surgery. A small number of patients, who are unwilling to undergo surgery or have contraindications to surgery, can choose oral anti-inflammatory drug therapy to relieve symptoms, mainly anti-inflammatory drugs covering aerobic and anaerobic bacteria in the intestinal tract. However, it should be noted that oral medication alone has limited effect in the treatment of appendicitis and can control the symptoms to some extent, but is prone to recurrence. Therefore, for patients who meet the indications for surgery, early surgical treatment to remove the appendix is recommended. With the development of medical technology, most of the appendicitis surgeries can now be performed by minimally invasive methods, which are simple to perform, and patients can recover quickly after surgery with few complications and a good prognosis.