Lung nodules found after vaccination are usually not directly related to the new coronavirus vaccine. Lung nodules need to be treated by observation, puncture or prompt surgical resection, and further diagnosis will be made based on pathologic findings. Neocoronavirus vaccine is mainly used to prevent neocoronavirus pneumonia. There are some adverse reactions to the vaccine, and it is common for patients to have allergic reactions, such as rash and urticaria, but there is no direct link between lung nodules and the vaccine. Lung nodules are more common in clinical practice. With the increase of life and social pressure, environmental pollution, smoking and other hazards, as well as the popularization of lung CT, the detection rate of lung nodules has increased. Lung nodules smaller than 10mm are clinically referred to as small nodules, and those smaller than 5mm are called micronodules. When a pulmonary nodule is detected, it is necessary to observe whether the boundary of the nodule is clear, whether the internal echoes are regular, whether the blood flow signal is rich, and whether there are signs of malignancy. If there are signs of malignancy or the nodule is large, it can be surgically removed. If there are no such problems, observation is recommended, and follow-up can usually be done at 3 months, 6 months, 12 months, and 24 months. If you find lung nodules, you should go to the respiratory medicine department of the regular hospital in time. Tips] In this article, “new coronary pneumonia, new coronary virus pneumonia” has been renamed to “new coronary virus infection” on December 26, 2022, as announced by the National Health Commission.