Can not be interested in anything, the main reasons are the following: 1, encountered a relatively high pressure things and other psychosocial factors, so that they become uninterested in a short period of time, and even things that were previously interested in now do not want to do. Common reasons such as high work pressure, study pressure, interpersonal tension, husband and wife relationship problems, economic pressure and so on are possible. These stressful events, as triggering factors, are likely to make people depressed, anxious and irritable, and thus not interested in anything. 2, it is possible that more serious people exist in a depressed mood, not happy, not even interested in anything, and always in this state for a long time, it may be a problem of depression. Depression as a common psychosomatic disease, the impact on interest is very huge. 3, there may be a certain personality or character defects. For example, patients with paranoia or schizoid personality disorder can be particularly withdrawn, lack of interest, or even no desire or motivation to do anything, when it is easy to not be interested in anything, and no motivation to interact with people, etc. The above aspects may be the cause of the decline in interest, and must be actively treated and intervened in symptomatically.