There is a difference between dydrogesterone and progesterone mainly in terms of composition, effects and adverse reactions. 1. Composition: the composition of dydrogesterone tablets is mainly progesterone, which can be supplemented with progesterone alone. Progesterone is a natural progesterone, the composition of which is progesterone, and the molecular structure of dydrogesterone tablets is different from the molecular structure of its own natural progesterone. 2.Role: Dydrogesterone treats diseases caused by endogenous progesterone, such as dysmenorrhea, amenorrhea, endometriosis and other diseases. Progesterone treats diseases caused by a lack of progesterone in the body, such as premenstrual abortion, habitual abortion, premenstrual tension syndrome, luteal insufficiency and other diseases. 3. Adverse effects: Adverse effects of dydrogesterone include vaginal bleeding, breast pain or tenderness, nausea, abdominal pain, migraine or headache. Adverse effects of progesterone include abdominal pain, constipation, nausea, anaphylactic-like reactions, muscle cramps, headache and so on. The adverse effects of progesterone are more serious than those of dexamethasone, which can be considered a derivative of progesterone and is more easily absorbed and utilized by the body, and appears to have milder adverse effects. It is recommended to go under the guidance of a doctor to choose the drugs of Dydrogesterone or Progesterone to treat the disease.