Hiccups after three days may be due to physiological factors such as catching a cold, or gastrointestinal dysfunction, reflux esophagitis, central neuropathy and so on. 1. Physiological factors: carbon dioxide gas produced after drinking a lot of carbonated beverages, stimulation caused by hiccups; the environmental temperature is too cold, resulting in cold, stimulating the diaphragm contraction and hiccups, which are physiological factors. 2. Gastrointestinal dysfunction: Eating cold and spicy stimulating food, overeating and other factors lead to gastrointestinal smooth muscle dysfunction, peristalsis is weakened, indigestion and food stagnation, so hiccups for three days. 3. Reflux esophagitis: due to the lower esophageal sphincter dysfunction and other factors cause gastric acid reflux, corrosion and irritation of the esophagus, resulting in hiccups, acid reflux, heartburn and other symptoms. 4. Central neuropathy: cerebral hemorrhage, cerebral infarction, central nervous system infection, traumatic brain injury and other conditions lead to local neuron damage in the brain, dysfunction, stimulation of diaphragm contraction spasm and hiccups. Hiccups for three days may also be esophageal hiatal hernia, esophagitis, hepatobiliary and pancreatic diseases and cardiac diseases, if not relieved, should be promptly consulted.