The purple spots on the legs of SLE patients are considered to be related to the blood clotting dysfunction caused by the disease, and patients should pay attention to it. Systemic lupus erythematosus is a chronic, recurrent autoimmune disease that often involves multiple organs and systems. Some SLE patients may have a decrease in platelet count, causing blood clotting disorders and purple spots on the legs. Some SLE patients may also have other symptoms such as skin and mucous membrane ulcers, hair loss, fever, ischemic necrosis of the fingertips, and arthralgia, which have a serious impact on the quality of life and health. In addition, when SLE involves other organs, it may manifest as headache, elevated blood pressure, edema, palpitation and dry mouth. It is recommended that patients with SLE causing purple spots on legs should go to the rheumatology department of regular hospitals and follow the doctor’s instructions.