Five times the seed has astringent fire, cough and sweat, astringent diarrhea (by enhancing the astringent function of the intestinal tract to alleviate diarrhea), fixing sperm and stopping spermatorrhea (consolidation of semen, prevention and control of spermatorrhea), astringent hemorrhagic (astringent drugs to treat bleeding conditions), astringent dampness and astringent sores and other effects. Five times can be used for the treatment of lung fever, coughing and hemoptysis, treatment of spontaneous sweating (involuntary sweating during the day, the slightest movement of sweating is aggravated) night sweating (abnormal sweating after sleeping, waking up sweating to stop), the treatment of prolonged diarrhea and long diarrhea, the treatment of ejaculation, spermatorrhea, the treatment of leakage (menstrual bleeding or excessive or more than a few drops of blood) bleeding, blood in the stool, hemorrhoidal bleeding, but also to treat eczema, sores and other diseases. Modern pharmacological studies of five times the seeds have astringent, protective wound, astringent small intestine, reduce intestinal inflammation to relieve diarrhea, antibacterial and other pharmacological effects. Adverse reactions: five times the seeds have astringent effect, damp-heat diarrhea, damp-heat dysentery (dysentery caused by damp-heat evil) patients should not be used, may aggravate the symptoms; five times the seeds taken on an empty stomach may lead to abdominal pain, diarrhea, nausea and vomiting, constipation and other gastrointestinal symptoms. Five times can be taken internally or externally. Internal use is mainly decoction, 3~9g/day, can also be made into pills, powder; external use can be powdered and applied externally, can also be boiled and washed externally. It is recommended to use under the guidance of a doctor.